Disease Area References

Cytology
Marchevsky, A et al. 2003. Virtual microscopy as a tool for proficiency testing in cytopathology. Arch Pathol Lab Med. 127: 1320-1324. Dept of Pathology and Lab Med, Cedars-Sinai Medical Center, Los Angeles, California.

Diabetes
Baggio, L. et al. 2008. An Albumin-Exendin- 4 Conjugate Engages Central and Peripheral Circuits Regulating Murine Energy and Glucose Homeostasis Gastroenterology 134:1137–1147.

Hadjiyanni, I. et al. 2008. Exendin-4 Modulates Diabetes Onset in Nonobese Diabetic Mice. Endocrinology 149(3):1338– 1349.

Király, M et al, 2008. Swim training prevents hyperglycemia in ZDF rats: mechanisms involved in the partial maintenance of beta-cell function. American Journal of Physiology - Endocrinology and Metabolism 294:271-283.

Kiraly, M et al. 2007. Attenuation of type 2 diabetes mellitus in the male Zucker diabetic fatty rat: the effects of stress and nonvolitional exercise. Metabolism Clinical and Experimental 56: 732-744.

Lamont, B.J. and Drucker, D.J. 2008. Differential Antidiabetic Efficacy of Incretin Agonists Versus DPP-4 Inhibition in High Fat–Fed Mice. Diabetes 57: 190-198.

Manneras, L. 2007. A New Rat Model Exhibiting Both Ovarian and Metabolic Characteristics of Polycystic Ovary Syndrome. Endocrinology 148(8) 3781-3791.

Soltani, N et al. 2007. In vivo expression of GLP-1/lgG-FRc fusion protein enhances beta cell mass and protects against streptozotoc in induced diabetes. Gene Therapy 14: 981-988.

Wong, DW. 2007. Dept of Med, Univ of Toronto, Ontario, Canada. Loss of Angiotensin- Converting Enzyme-2 (Ace2) Accelerates Diabetic Kidney Injury. American Journal of Pathology 171:438-451.

Hematology
Burman, A et al. 2007. IFN differentially controls the development of idiopathic pneumonia syndrome and GVHD of the gastrointestinal tract. Blood 110: 1064-1072. Queensland Institute of Medical Research, Herston.

Lee, S. 2005. Virtual microscopy: Applications to hematology. Laboratory Hematology 11:38-45. Division of Haematology, Institute of Med and Vet Science, Adelaide, Australia.

Luciano, F et al. 2007. Nur77 converts phenotype of Bcl-B, an antiapoptotic protein expressed in plasma cells and myeloma. Blood 109:3849-3855. Burnham Institute for Medical Research, La Jolla, California.

Hepatology
Best, D and Coleman, W. 2007. Treatment with 2-AAF blocks the small hepatocyte-like progenitor cell response in retrorsine-exposed rats. Journal of Hepatology 46: 1055-1063. Dept of Path and Lab Med, UNC Lineberger Comprehensive Cancer Center, Univ of North Carolina, School of Med, Chapel Hill, North Carolina.

Fan, J et al. 2007. Saikosaponin-d attenuates the development of liver fibrosis by preventing hepatocyte injury. Biochem Cell Biol 85: 189-195. Faculty of Pharmacy, University of Manitoba, Winnipeg, Canada.

Folberg, R et al. 2007. Modeling the behavior of uveal melanoma in the liver. Invest Ophthalmology & Visual Science 48: 2967- 2974. Dept of Pathology, University of Illinois at Chicago, Chicago, Illinois.

Microbiology
de Swart, R et al. 2007. Predominant infection of CD150+ lymphocytes and dendritic cells during measles virus infection of Macaques. PLoS Pathogens 3(11):e178. Dept. of Virology, Erasmus MC, Univ Med Center, Rotterdam, The Netherlands.

Kobayashi, A et al. 2004. Functional attributes of mucosal immunity in cervical intraepithelial neoplasia and effects of HIV infection. Cancer Research 64: 6766-6774. The Cancer Research Institute and Department of Obstetrics, Gynecology, and Reproductive Sciences, UCSF, San Francisco, California.

Lemon, K et al. 2007. The F Gene of rodent brain-adapted mumps virus is a major determinant of neurovirulence. Journal of Virology 81(15): 8293-8302. School of Biomedical Sciences, The Queen's Univ of Belfast, Belfast, United Kingdom.

Nguyen, M et al. 2007. Mice Lacking NKCC1 are protected from development of bacteremia and hypothermic sepsis secondary to bacterial pneumonia. Journal of Experimental Medicine 204(6): 1383-1393. Dept of Genetics, University of North Carolina, Chapel Hill, North Carolina.

Mouse Biology
Liao, C et al. 2007. Mouse models of prostate adenocarcinoma with the capacity to monitor spontaneous carcinogenesis by bioluminescence or fluorescence. Cancer Res 67(15): 7525-7533. Dept of Biochemistry and Molecular Biology, Keck School of Med, University of Southern California, Los Angeles, California.

Pan, T et al. 2005. Virtual mouse placenta: tissue layer segmentation. IEEE. Dept of Biomedical Informatics, Ohio State University, Columbus, Ohio.

Neuroscience
Amici, S et al. 2006. Peripheral Myelin Protein 22 Is in Complex with alpha 6 beta 4 Integrin, and Its Absence Alters the Schwann Cell Basal Lamina. J Neuroscience 26(4): 1179-1189. McKnight Brain Institute, Univ of Florida, Gainesville, Florida.

Guzman, M. and Judkins, A. 2009. Digital Pathology: A Tool for 21st Century Neuropathology. Brain Pathology 19: 305–316. Dept of Path and Lab Med, Div of Neuropath, Univ of Pennsylvania Med Center.

Lowe, X et al. 2007. The expression of Troponin T1 gene is induced by ketamine in adult mouse brain. Brain Research 1174: 7- 17. Life Science, Lawrence Berkeley Natl Lab, Berkeley, California.

Mikula, S et al. 2007. Internet-enabled high resolution brain mapping and virtual microscopy. NeuroImage 35: 9-15. Center for Neuroscience University of California, Davis, California.

Sinclair, C et al. 2007. Absence of aquaporin- 4 expression in lesions of neuromyelitis optica but increased expression in multiple sclerosis lesions and normal-appearing white matter. Acta Neuropathol 113:187-194. Neuropathology Lab, Institute of Pathology, Belfast, N. Ireland, UK.

Tallini, Y et al. 2006. BAC transgenic mice express enhanced green fluorescent protein in central and peripheral cholinergic neurons. Physiological Genomics 27: 391-397. Biomedical Science Dept, College of Vet Med, Cornell University, Ithaca, New York.

Oncology
Achcar, R et al. 2007. Expression of activated and latent signal transducer and activator of transcription 3 in 303 non-small cell lung carcinomas and 44 malignant mesotheliomas. Arch Pathol Lab Med. 131:1350-1360. Dept of Pathology, Univ of Texas Health Sciences Center, San Antonio, Texas.

Bjorling, E et al. 2007. A web-based tool for in silico biomarker discovery based on tissue-specific protein profiles in normal and cancer tissues. Molecular & Cellular Proteomics. School of Biotechnology, AlbaNova University Center, Royal Institute of Tech, Stockholm, Sweden.

Breitbach, C et al. 2007. Targeted inflammation during oncolytic virus therapy severely compromises tumor blood flow. American Society of Gene Therapy. Centre for Cancer Therapeutics, Ottawa health Research Institute, Ottawa, Ontario, Canada.

Cao, P et al. 2009. Activity of a novel, dual PI3-kinase/mTor inhibitor NVP-BEZ235 against primary human pancreatic cancers grown as orthotopic xenografts. British Journal of Cancer. 100: 1267–1276. Department of Medical Oncology and Hematology, Ontario Cancer Institute/Princess Margaret Hospital, University of Toronto, Ontario, Canada.

Cardiff RD, et al. 2007. The Tumor Pathology of Genetically Engineered Mice: A New Approach to Molecular Pathology. In: Fox JG et al, ed. The Mouse in Biomedical Research: Experimental Biology and Oncology Second ed. New York: Elsevier, Inc 2006:581-622. Dept of Pathology and Lab Med, Center for Comparative Med, University of Davis, Davis, California.

Challacombe, J et al. 2006. Neutrophils are a key component of the antitumor efficacy of topical chemotherapy with ingenol-3-angelate. The Journal of Immunology 177:8123-8132. Queensland Institute of Medical Research, Brisbane, Queensland, Australia.

Connolly, D et al. 2003. Female mice chimeric for expression of the simian virus 40 TAg under control of the MISIIR promoter develop epithelial ovarian cancer. Cancer Research 63: 1389-1397. Ovarian Cancer Program, Div of Med Sciences, Fox Chase Cancer Center, Philadelphia, Pennsylvania.

Davies, N and Wilson, B. 2007. Interstitial in vivo ALA-PpIX mediated metronomic photodynamic therapy (mPDT) using the CNS-1 astrocytoma with bioluminescence monitoring. Photodiagnosis and Photodynamic Therapy 4: 202-212. Dept of Med Biophysics, University of Toronto, Toronto, Canada.

Dee, F et al. 2003. Implementation of virtual microscope slides in the annual pathobiology of cancer workshop laboratory. Human Pathology 34:430-436. Dept of Pathology, Carver College of Med, Univ of Iowa, Iowa City, Iowa and Dept of Pathology, Brody School of Med, East Carolina Univ, Greenville, North Carolina.

Evans, A et al. 2007. VHL promotes E2 boxdependent E-Cadherin transcription by HIFmediated regulation of SIP1 and snail. Molecular and Cellular Biology 27(1): 157- 169. Dept of Lab Med and Pathobiology, Faculty of Med, Univ of Toronto, Toronto, Ontario, Canada.

Gervais, ML. et al. Nuclear E-cadherin and VHL immunoreactivity are prognostic indicators of clear-cell renal cell carcinoma. Lab Invest. 87(12):1252-64. Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Iakovlev VV et al. 2007. Effect of distributional heterogeneity on the analysis of tumor hypoxia based on carbonic anhydrase IX. Lab Invest. 2007 87(12):1206-17. Ontario Cancer Institute, Princess Margaret Hospital, Toronto, ON, Canada.

Kalliomäki, T. 2009. Progression and metastasis in a transgenic mouse breast cancer model: Effects of exposure to in vivo hypoxia. Cancer Letters. 282: 98-108. Applied Molecular Oncology Division, Ontario Cancer Institute/Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada

Kobayashi, A et al. 2004. Functional attributes of mucosal immunity in cervical intraepithelial neoplasia and effects of HIV infection. Cancer Research 64: 6766-6774. The Cancer Research Institute & Dept of Obstetrics, Gynecology, and Reproductive Sciences, Comprehensive Cancer Center at Univ of CA at San Francisco, San Francisco, California.

Kong, J et al. 2007. A new multiresolution analysis framework for classifying grade of neuroblastic differentiation. OSU BMI Technical Report. The Ohio State University, Dept. of Electrical & Computer Engineering, Dept. of Biomedical Informatics, Columbus, Ohio.

Krajewska, M et al. 2007. Claudin-I immunohistochemistry for distinguishing malignant from benign epithelial lesions of prostate. The Prostate 67: 907-910. Burnham Institute for Medical Research, La Jolla, California.

Liao, C et al. 2007. Mouse models of prostate adenocarcinoma with the capacity to monitor spontaneous carcinogenesis by bioluminescence of fluorescence. Cancer Research 67(15): 7525-33. Dept of Biochemistry and Molecular Biology, Keck School of Med, Univ of Southern California, Los Angeles, California.

Liu, J et al. 2006. Integrin-linked kinase inhibitor KP-392 demonstrates clinical benefits in an orthotopic human non-small cell lung cancer model. Journal of Thoracic Oncology. 1:771-779. Division of Thoracic Surgery, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada.

Lucchese, A et al. 2005. Proteomic scan for tyrosinase peptide antigenic pattern in vitiligo and melanoma: role of sequence similarity and HLA-DR1 affinity. The Journal of Immunology 175: 7009-7020. Dept of Odontostomatology and Surgery, University of Bari, Bari, Italy.

Luciano, F et al. 2007. Nur77 converts phenotype of Bcl-B, an antiapoptotic protein expressed in plasma cells and myeloma. Blood 109(9): 3849-3855. Burnham Institute for Medical Research, La Jolla, California.

Miller, SL et al. 2007. Nek3 kinase regulates prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells. Oncogene 26: 4668-4678. Dept of Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, New York.

Mocanu, J et al. 2007. Imaging the modulation of adenoviral kinetics and biodistribution for cancer gene therapy. Molecular Therapy 15(5): 921-929. Dept of Med Biophysics, Univ of Toronto, Toronto, Ontario, Canada.

Mocanu, J. et al. 2007. Imaging and modulating antisense microdistribution in solid human xenograft tumor models. Clinical Cancer Research 13(19): 5935-5941. Division of Applied Molecular Oncology, Ontario Cancer Institute, Ontario, Canada.

Mosaliganti, K et al. ITK-based registration of large images from light microscopy: a biomedical application. Dept of Computer Science & Engineering, Ohio State University, Columbus, Ohio.

Nam, J et al. 2009. An anti-TGF-β antibody suppresses metastasis via cooperative effects on multiple cell compartments. Cancer Res. 68(10): 3835–3843. Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science, Incheon, Korea.

Nikitin, A et al. 2004. Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortium. Cancer Research 64: 2307-2316. Dept of Biomedical Sciences, College of Vet Med, Cornell University, Ithaca, New York.

Pham, N et al. 2007. Quantitative image analysis of immunohistochemical stains using a CMYK color model. Diagnostic Pathology 2(8). Div of Applied Molecular Oncology, Ontario Cancer Institute/Princess Margaret Hospital, University Health Network, Toronto, Canada.

Pitt-Francis, J et al. 2006. Multimodal imaging techniques for the extraction of detailed geometrical and physiological information for use in multi-scale models of colorectal cancer and treatment of individual patients. Computational and Mathematical Methods in Medicine 7(2-3): 177-188. Oxford Univ Computing Lab, Oxford, United Kingdom.

Raimondi, A et al. 2006. Rapid development of salivary gland carcinomas upon conditional expression of K-ras driven by the cytokeratin 5 promoter. American Journal of Pathology 168(5): 1654-1665. Oral & Pharyngeal Cancer Branch, National Institute of Dental Research, NIH, Bethesda, Maryland.

Sharp, R et al. 2007. Volume rendering phenotype differences in mouse placenta microscopy data. Computing in Science & Engineering 9(1):38-47. Ohio State University.

Stewart, J et al. 2006. Comparison of annexin II, p63 and AMACR immunoreactivity in prostatic tissue: a tissue microarray study. Journal Clinical Pathology. 60: 773-780. Dept of Pathology, Toronto General Hospital, Toronto, Ontario, Canada.

Trempus, C et al. 2007. CD34 expression by hair follicle stem cells is required for skin tumor development in mice. Cancer Res 67(9): 4173-4181. Cancer Biology Group, Lab of Molecular Toxicology, US Environmental Protection Agency, Research Triangle Park, North Carolina.

Tse, K et al. 2007. MCP-1 promoter polymorphism at -2518 is associated with metastasis of nasopharyngeal carcinoma after treatment. Clin Cancer Res 13(21): 6320- 6326. Institute of Microbiology and Immunology, National Yang-Ming Univ, Taipei, Taiwan.

Turovskaya, O et al. 2008. RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis. Carcinogenesis. 29(10):2035-2043. Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA.

Uhlen, M et al. 2005. A human protein atlas for normal and cancer tissues based on antibody proteomics. Molecular & Cellular Proteomics 4:1920-1932. Dept of Biotechnology, AlbaNova Univ Center, Royal Institute of Technology, Stockholm, Sweden.

Wang, Y. et al. 2007. Investigation of Methodologies for the Segmentation of Squamous Epithelium from Cervical Histological Virtual Slides. Machine Vision and Image Processing 2007. IMVIP. Queen's University, Belfast, United Kingdom.

Wang, Y. et al. 2007. Segmentation of Squamous Epithelium from Ultra-large Cervical Histological Virtual Slides. Engineering in Medicine and Biology. 29th Annual International Conference of the IEEE. Queen's University, Belfast, United Kingdom.

Wenzel, P et al. 2007. Rb is critical in a mammalian tissue stem cell population. Genes & Dev. 21:85-97. Human Cancer Genetics Program, College of Med, The Ohio State University, Columbus, Ohio.

Whiteford, C et al. 2007. Credentialing preclinical pediatric xenograft models using gene expression and tissue microarray analysis. Cancer Res 67(1): 32-40. Oncogenomics Section, NIH, Bethesda, Maryland.

Wiederschain, D et al. 2007. Contribution of polycomb homologues Bmi-1 and Mel-18 to medulloblastoma pathogenesis. Molecular and Cellular Biology 27(13): 4968-4979. Oncology Research, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts.

Wong, HL et al. 2007. In vivo evaluation of a new polymer-lipid hybrid nanoparticle (PLN) formulation of doxorubicin in a murine solid tumor model. European Journal of Pharmaceutics and Biopharmaceutics 65: 300-308. Graduate Dept of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada.

Yang, L et al. 2007. High throughput analysis of breast cancer specimens on the grid. MICCAI 2007, Part 1, LNCS 4791: 617-625. Dept. of Electrical and Computer Eng., Rutgers Univ, Piscataway, New Jersey.

Yang, X et al. 2007. Differences in risk factors for breast cancer molecular subtypes in a population-based study. Cancer Epidemiol Biomarkers Prev 16(3): 439-443. Division of Cancer Epidemiology and Genetics, NIH, Bethesda, Maryland.

Yang, X et al. 2007. Hormonal markers in breast cancer: coexpression, relationship with pathologic characteristics, and risk factor associations in a population-based study. Cancer Res 67(21): 10608-10617. Div of Cancer Epidemiology & Genetics, NIH, Bethesda, Maryland.

Yoshimoto, M et al. 2007. FISH analysis of 107 prostate cancers show that PTEN genomic deletion is associated with poor clinical outcome. British Journal of Cancer 1- 8. Division of Applied Molecular Oncology, Ontario Cancer Institute, Princess Margaret Hospital , Toronto, Ontario, Canada.

Zhang, L et al. 2007. Hypoxia enhances metastatic efficiency in HT1080 fibrosarcoma cells by increasing cell survival in lungs, not cell adhesion and invasion. Cancer Res 67(16): 7789-7797. Research Division, Ontario Cancer Institute/Princess Margaret Hospital, Toronto, Ontario, Canada.

Zhou, Z et al. 2007. Prostate cancer associated with p53 and Rb deficiency arises from the stem/progenitor cell-enriched proximal region of prostatic ducts. Cancer Res 67(12): 5683-5690. Dept of Biomedical Sciences, Cornell University, Ithaca, New York.

Ophthalmology
Folberg, R et al. 2007. Modeling the behavior of uveal melanoma in the liver. Investigative Ophthalmology and Visual Science. 48: 2967-2974. Dept of Pathology, University of Illinois at Chicago, Chicago, Illinois.

Yaacobi, Y et al. A novel, automated, high throughput, retinal ganglion cell counting system. Alcon Research, Ltd., Fort Worth, Texas.

Stem Cells
Trempus, C et al. 2007. CD34 expression by hair follicle stem cells is required for skin tumor development in mice. Cancer Research 67(9): 4173-4181. Cancer Biology Group, Lab of Molecular Toxicology, US Environmental Protection Agency, Research Triangle Park, North Carolina.

Wenzel, P et al. 2007. Rb is critical in a mammalian tissue stem cell population. Genes & Dev 21: 85-97. Human Cancer Genetics Program, The Ohio State University, Columbus, Ohio.

Transplantation
Burman, A et al. 2007. IFN differentially controls the development of idiopathic pneumonia syndrome and GVHD of the gastrointestinal tract. Blood 110: 1064-1072. Queensland Institute of Med Research, Herston.

Einecke, G et al. 2006. Tubulitis and epithelial cell alterations in mouse kidney transplant rejection are independent of CD103, perforin or granzymes A/B. American Journal of Transplantation 6: 2109- 2120. Dept of Med, Division of Nephrology and Transplantation Immunology, University of Alberta, Edmonton, Canada.

Zebrafish Histology
Sabaliauskas, N et al. 2006. High-throughput zebrafish histology. Methods 39:246-254. Jake Gittlen Cancer Research Foundation, Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania.